Berberine is multi-targets therapeutic weapon; medical biotechnology resolves the mystery
It is well known that berberine has several biological activities like antioxidants, anti-inflammatory, antidiabetic, antilipidemic and antitumor properties. Unfortunately, this compound does not use as drug because it has low bioavailability moreover, the plant that contains this compound is not cultivated in Egypt. The aim of this review was to understand the function of berberine as a treatment for Alzheimer and the role of biotechnology in berberine optimization process. To achieve this aim, the anti-Alzheimer effect of this compound at in silico, in vitro and in vivo level through targeting several pathways implicated in disorder incidence and progression was discussed. Moreover, two approaches in medical biotechnology field were used to resolve berberine problems which are Biocatalysis and nano-formulations. In conclusion, berberine loaded nanoparticle is good candidate to treat Alzheimer through targeting several pathways with no-toxic effect and high therapeutic index.